Broad spectrum anthelmintics are effective against parasitic flat worms and nematodes. However, the majority of drugs are more limited in their action, e.g., praziquantel, a drug used in the treatment of schistosomiasis and thought to act by disrupting calcium homeostasis (Greenberg, 2005), has no activity against nematodes (see Table 1). For the purpose of this review we will focus on drugs used in human and veterinary medicine to treat parasitic nematode infection.
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